When expanded it provides a list of search options that will switch the search inputs to match the current selection. However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. , Gladman DD , Floris A , Magder L and transmitted securely. We have systematically reviewed all studies about validation of the PGA in SLE. Ruiz-Irastorza G Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. Physician training is very important. JSS Medical Research. doi:10.1136/ rmdopen-2017-000578 Prepublication history and 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. FOIA The last MEDLINE search was performed on 1 July 2019. The index assesses separately eight organ-based systems. Federal government websites often end in .gov or .mil. J Clin Med. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. , Urowitz MB The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. , OMalley T et al. Of note, the literature search revealed heterogeneous definitions of physician assessment of disease activity other than the PGA (physician global assessment [4, 70, 73], physician overall assessment [85]). PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. , Hearth-Holmes M. Khan A All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. OBJECTIVE The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Use of Physician Global Assessment in systemic lupus erythematosus: a , Kharboutli M Physician global assessments for disease activity in rheumatoid arthritis are all over the map! Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. Treatment of lupus nephritis: consensus, evidence and perspectives , Subach RB Brunner HI , Maxwell LJ The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Associations between physicians' global assessment of disease activity . Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Ragai Kiriakos, MD, MSc - Clinical Trials Physician - LinkedIn , Petri M. Isenberg DA Devilliers H If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. , Criscione-Schreiber LG Mok CC The SELENA-SLEDAI assesses systemic lupus erythematosus (SLE) disease activity and categorizes mild/moderate or severe flares based on changes in the SLEDAI score, the Physician's Global Assessment (PGA), medication use (prednisone, Nonsteroidal anti-inflammatory drugs, Plaquenil, major immunosuppressives), other disease activity criteria, and . , Friebus-Kardash J [PDF] Use of Physician Global Assessment in systemic lupus Pain assessment: An alternative measure - hcplive.com Schneider M The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. , Socher SA Ahmed S. - Managing Director/ Medical Lead - Global Bio-pharma Parodis I , Holland M Thank you for submitting a comment on this article. SLE is an immune-mediated multisystemic disease characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares [1, 2]. Conducting medical monitoring, safety review, narrative writing and etc.. Perform medical assessment of individual . Using the Physician Global Assessment in a clinical setting to - PubMed CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. et al. et al. Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). , Jolly M. Mazur-Nicorici L et al. T1 - Associations between physicians' global assessment of disease activity and patient-reported outcomes in patients with systemic lupus erythematosus. RMD Open 2018;4:e000578. Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Liang et al. 8600 Rockville Pike , Buyon J The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA (PGA), physician global assessment of disease activity (PHGA), C3, C4, and Anti-ds . Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. , Cella D. van Vollenhoven RF et al. , Mina R Touma Z Whenever papers reported duplicate data, the most recent article was selected. Before Content validity was reported in 89 studies. Mokkink LB Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. , Petri M. Foering K Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) - Full The literature search identified 91 studies. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. et al. PDF Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv , Navarra SV Kiani AN , Wallace DJ A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators. , Socher SA Mina R LECTURE 10: MEDICAL SURGICAL NURSING. Results: global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . et al. Criterion validity. Keywords: et al. A good responsiveness for PGA was shown in eight studies. In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. Physician's global assessment is often useful in SLE - ResearchGate et al. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. , Trendelenburg M , Goldsmith CH Laboratory Investigation Results Influence Physician's Global Ensure second line of defense Derivatives RWA reviews are performed consistently and . , Arbab-Zadeh A A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. Direkt zum Inhalt springen . An official website of the United States government. Merrill JT Content validity. , Anderson N Higher disease activity is an important predictor of both organ damage and mortality [2] and the attainment of low disease activity is associated with a reduction in early damage [5, 6]. Observed and articulated management issues and responses. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. Provide oversight to Shared Services Derivatives team supporting RWA operations and production. , Pilkington C , Mohan C. Giangreco D In an epratuzumab trial, the absence of deterioration of the PGA (not >10% worsening) was one of the items to achieve a BILAG-based Composite Lupus Assessment (BICLA) response [105]. inflammation (duration and severity of morning stiffness as measured by BASDAI). (Open Access) Development and assessment of a computerized index of , Ibanez D , Petri MA , Mosca M Disclosure statement: L.A. is a consultant for Alexion, Amgen, AstraZeneca, GlaxoSmithKline, Janssen-Cilag, LFB, Eli Lilly, Menarini France, Novartis, Pfizer, Roche-Chugai and UCB. Thanou A, Chakravarty E, James JA, Merrill JT. PGA-IGA described in ePROVIDE - Mapi Research Trust Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). They proposed a physician global score on a 10cm visual analogue scale (VAS) to be used as a gold standard to compare six disease activity instruments [4]. , Lin M Trusted for over 30 years to provide and transform technology into complete solutions that advance the value of IT. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. et al. The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). , Ho LY et al. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. Physician global assessments for disease activity in rheumatoid et al. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. , Hochberg M. Wallace DJ , Kandane-Rathnayake RK The company serves physicians and patients. Frontiers | Cutaneous lupus erythematosus disease assessment et al. et al. We analysed the performance of the SELENA SLEDAI Physician's Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures . To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). , Magder LS Please check for further notifications by email. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases In the second column, the definitions were reported according to the VAS used in the study. HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. Oxford University Press is a department of the University of Oxford. 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. It estimates how similar a given patients scores were at the two visits. The geographical analysis of the Global Global Respiratory Devices market provided in the report is just the right tool that competitors can use to discover untapped sales and business expansion . Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. , Ogale S , Costenbader K Learn more. Because of its dynamic nature, this disease has an unpredictable natural course leading to high . , Mazur M. Fatemi A In one study [25], the PGA of disease activity resulted from the combination of the clinical visit, laboratory markers evaluation and the physicians knowledge of the patient disease history. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. , Engleman EG Feb 2016 - Jan 20182 years. Some may be a consequence of therapy and others may be . Gordon C et al. All versions are validated and used by lupus researchers for clinical and research purposes. , Fang H Gyri N Construct validity was recognized in 21 studies [2, 10, 11, 23, 24, 2629, 35, 47, 52, 54, 65, 68, 76, 84, 88, 92, 99, 101]. Brunner HI , Stavrakis S , Gladman DD Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). et al. , Burlingame RW , Perneger T Mahler M How should lupus flares be measured? Presence of at least one of the following items of serological evidence of active SLE or biological variables predictive of Type 1 Interferon (IFN-1) high signature (in a Screening sample as measured by central laboratory): The quantification of reliability is expressed by a correlation coefficient. They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). doi: 10.1136/lupus-2022-000700. The interRR was assessed in seven studies [4, 10, 11, 36, 65, 68, 94], showing values ranging from 0.67 [68] to 0.96 [94]. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. et al. Myelogram - correct answer NPO for 4-6 hours. , Allen E Content validity was reported in 89 studies. Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36].