Participants were randomly allocated to four treatment arms and randomly assigned with OTC dentifrices having FCPS, Pro-argin, strontium acetate, and sodium fluoride (NaF) with an allocation ratio of 1:1:1:1. 2020;12(2):87. A head-to-head comparative evaluation of these most effective bioactive agents, such as arginine and BAG-based desensitisers, was suggested by Martins et al. reporting the instant relief from DH by 44.1% with Pro-argin on SCASS. The mean scores with repeated measures were statistically analysed at each time point for study outcomes. Pro-Argin technology is occlusive. 2020;99(5):51422. The Gum Health Physical is a new interactive digital tool you can use to quickly evaluate your patients in-office, and give them a personalized report they can use at home. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste contains Sodium Fluoride (1450ppmF) the recommended fluoride level for effective caries prevention.4. Table 4 demonstrates a comparison between treatment groups observing better clinical efficacy in managing DH on SCASS. Tel: +381 (0)21 452-910, +381 (0)21 420-758. Comparative evaluation of desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate: a randomized controlled clinical trial. Amsterdam: Elsevier; 2015. p. 4576. YES Somewhat No Shiau HJ. Plain bi-carb soda and coconut butter do a far better job at cleaning and desensitising. 1997;24(11):80813. Work with Colgate Professional to help provide better oral care to your patients. Product Details Characteristics and Benefits Characteristics: Unique Pro-Argin TM/MC technology based on natural process of tubule occlusion Poster #0742, March 2018 AADR. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. There was no statistically significant treatment difference between the two (p=0.499). Mockdeci H, Polonini H, Martins I, Granato A-P, Raposo N. Evaluation of ex vivo effectiveness of commercial desensitizing dentifrices. Gently removes stains and helps restore the natural whiteness of your teeth. Venkataramana S, Jeyaraman SK, Kothimbakkam SSK, Chellathurai BNK. 2020;20(3):101460. Friedman Test was used to observe post-application change in treatment responses within the group for 6weeks. WHAT IS Colgate SENSITIVE INSTANT Relief Repair & Prevent? Another study by Hines et al. Find products and services. Colgate Sensitive Instant Relief Repair & Prevent Toothpaste starts blocking sensitivity pain instantly*. 29,95 kr. Table 3 demonstrates the percent change in the mean scores of DH on SCASS relative to baseline within the group for each treatment arm. https://doi.org/10.1186/s12903-021-01864-x, DOI: https://doi.org/10.1186/s12903-021-01864-x. Am J Dent. 1):8A-15A. Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. [16] in a systematic review in 2015. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Children 6 years and younger: use a pea-sized amount for supervised tooth brushing to minimise swallowing. They reported more clinical efficacy with BioMin than Pro-argin reduction in air-blast stimulated DH on VAS after one month [39]. 75 ml. The statistically significant change in mean scores of DH was observed with FCPS with p<0.05 relative to baseline for sustained relief from DH at follow-ups on day 3, week 2, week 4, and week 6, using clinical parameters of SCASS and VAS. Register now and gain access to: 8 hours ECPD Product samples Patient materials Register here * For instant relief, apply directly to the sensitive tooth with finger tip and gently massage for 1 minute. Pro-Argin Technology with arginine and an insoluble calcium compound, zinc and 1450ppm fluoride. Blocks the pain of sensitive teeth. Colgate-Palmolive Company 2018. J Non Cryst Solids. 75 ml. Colgate Sensitive Pro-Relief Enamel Rebuild also: Fights cavities Strengthens enamel Freshens breath Vegan . A toothbrushing demonstration model from Nissin Company specification [PE-ORT002] was used to explain to the study participants about applying OTC dentifrices for one minute with the participant's finger. The prevalence of DH was found to vary from about 5 to 62% owing to the use of different diagnostic and measuring tools and age groups in the published literature, with the best average estimate of 34% worldwide [3]. YYYY Colgate-Palmolive Company. Am J Dent. J Clin Dent 2009; 20 (Spec Iss): 17-22. This clinical trial was approved by the Institutional Review Board of Dow University of Health Sciences (Ref: IRB-1351/DUHS/Approval/2019/184) and was registered under the protocol ID NCT04249336 (https://clinicaltrials.gov/ct2/show/NCT04249336) on January 30, 2020, in accordance with the CONSORT statement of the updated guidelines for reporting randomised clinical trials. Grnberg C, Bauer F, Crispin A, Jakob M, Hickel R, Draenert ME. It has stannous fluoride as an active ingredient. observed a significantly greater reduction in sensitivity from air and tactile stimuli when compared to a potassium ion toothpaste, an effect sustained at two, four and eight weeks of use. I am interested to hear you guys opinion and thought about it. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. The total sample size was 140 participants, with thirty-five in each group. Colgate Sensitive Pro Relief offers a solution that is clinically proven to relieve sensitivity pain. For children 6-12 years of age, once a week or less frequently. Yes, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste should be used for twice daily toothbrushing to provide ongoing relief from the pain of sensitive teeth. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. A previously published study by Samueli et al. Colgate Sensitive Instant* Relief Enamel Repair tandkrm ger dig kliniskt bevisad lngvarig lindring** mot ilningar i tta veckor nr du anvnder den tv gnger om dagen. Oral dentifrices were provided to the subject free of cost. Benefits: Colgate Sensitive Prevent and Repair is clinically proven to provide superior relief vs Sensodyne Extra Whitening at 8 weeks1 Long-lasting relief from hypersensitivity with continued use Superior sensitivity relief at 8 weeks vs the leading Sensodyne toothpaste variant 1 Hines D, Rinaudi L, Xu S, Lavender S, Pilch S: The Use of Confocal Laser Scanning Microscopy and a Novel Imaging Program for Quantifying Dentine Tubule Occlusion. Written informed consent was obtained with a signed agreement plan to visit for six weeks at interim efficacy intervals of day three, week two, week four, and week six. Last updated on May 11, 2021. With regular use, the Pro-Argin formula builds a long-lasting protective barrier that acts like a seal against sensitivity. Many patients tolerate the pain of sensitive teeth because theyre unaware of simple but highly effective answers like Pro-Argin technology. Two double-blind randomized clinical studies by Nathoo et al. The permanent management of DH is being investigated with the remineralisation potential of bioactive agents in dentinal tubules. Dentine hypersensitivity. Madurai: Best Dental Science College; 2020. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. In contrast, there was a significant (p<0.001) reduction of 61.1% with FCPS, 60.1% with Pro-argin, 53.4% with 8% strontium acetate, and 25% with NaF-based dentifrices relative to baseline after subsequent six weeks of application observing sustained relief from DH on SCASS. 2009;20(1):106. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste delivers instant* and long-lasting sensitivity relief plus gum protection. 4.4 5 0 198 198 Colgate Sensitive Pro-Relief Gum Therapy toothpaste helps instantly repair sensitive teeth and provides lasting protection against hypersensitivity. J Clin Dent 20 (2009), special issue 17-22, 3. When you recommend Colgate Sensitive Pro Relief, you can help your dentin hypersensitivity patients to enjoy a pain-free life, confident in the knowledge that youre providing a highly effective, evidence-based solution. While 8% strontium acetate showed a greater clinical reduction in water jet stimulated DH on VAS than Pro-argin at all efficacy intervals, as demonstrated in Table 6. KruskalWallis test was used to compare treatment groups. Provided by the Springer Nature SharedIt content-sharing initiative. *with direct application and daily brushing. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste for the daily oral care of patients with dentine hypersensitivity and gum problems. Provides 24/7 sensitivity protection. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. PREVENTS SENSITIVITY COMING BACK: Sealed channels protect against pain for instant relief, and with regular use provide lasting protection to prevent sensitivity from . However, we can conclude that both Pro-argin and strontium acetate-based dentifrices disrupt the pathophysiology of DH and are effective for immediate pain relief even one minute after application on sensitive teeth. J Clin Dent. With regular use, it creates a long-lasting protective barrier that acts as a seal against sensitivity. Colgate Sensitive Instant Relief Toothpaste starts blocking sensitivity pain instantly*. 2019;46(12):11216. Pashley D. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. The study's primary objective was to investigate pain relief in one minute after topical application of Pro-argin and strontium acetate on sensitive teeth in DH. The strength of this study was that participants were randomised into four treatment groups to generalise the results for the population [32]. 2015;28(1):404. They explored greater tubular occlusion potential and more acid resistance of Pro-argin in comparison to FCPS after subsequent seven days of application on dentinal discs [38]. This site is intended for healthcare professionals only. Bae J-H, Kim Y-K, Myung S-K. Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysis. Mintsmak. statement and PubMed Colgate Sensitive Pro-Relief Enamel Repair contains Pro-Argin formula, helping to remineralise enamel, strengthen teeth against acid in food and drinks, plus instantly plugs channels to sensitive nerves. Clinical efficacy of BioMin F, Colgate sensitive pro-relief and Sensodyne rapid action dentifrices in DH [Internet]. Effectiveness of dentifrices with new formulations for the treatment of dentin hypersensitivitya meta-analysis. Manage cookies/Do not sell my data we use in the preference centre. These then interact to form a complex with positive charge. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste is an everyday toothpaste. Department of Oral Biology, Dr. Ishrat-Ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Dow University of Health Sciences, Karachi, Pakistan, Department of Oral Biology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan, Department of Research, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan, You can also search for this author in The Pro-Argin technology repairs sensitive areas of the teeth for instant* and long-lasting sensitivity pain relief. Colgate Sensitive PRO-Relief Provides clinically proven, everyday protection from painful sensitivity. Click & Collect. If the enamel is too thin, has tiny tubules that reveal the underlying dentin, or is worn down in some places. While your patients may have dentine hypersensitivity in common, their oral care needs will vary. Modified bass brushing method was demonstrated on the same model before the first application of dentifrices in the dental clinic. 2020;99(5):51422. Docimo et al. Clinically proven amino acid formula with Pro-Argin technology to provide sensitivity relief. Felix J, Ouanounou A. Dentin hypersensitivity: etiology, diagnosis, and management. A total of 128 participants completed the trial. Can be used after the Colgate Sensitive Pro-Relief Desensitizing Paste. Colgate Sensitive Instant Relief Multiprotection Toothpaste gives you clinically proven lasting relief from sensitivity for 8 weeks when you use it twice a day. All the treatment groups showed statistically significant improvement in DH with p<0.001 relative to baseline at all time points. ^Vs novamin/sodium fluoride technology and stannous fluoride/sodium fluoride technology (p<0.05). Dentinal tubules occluded by bioactive glass-containing toothpaste exhibit high resistance toward acidic soft drink challenge. Sriranganathan D, Chen X, Hing KA, Kanwal N, Hill RG. 2009;20 (Spec Iss):123130. Google Scholar. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. A total of 140 participants were initially enrolled and randomised into the four treatment arms, with thirty-five in each group. 2017;2017:2. For instant relief, apply directly to the sensitive tooth with finger tip, and massage gently for 1 minute, once a week or less frequently. Post-hoc analysis revealed a significant reduction in DH scores in treatment arms compared to control on completing the six-week trial (p<0.05). 7 Ipsos, UK Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2 weeks trial, 192 respondents, 2016. Am J Dent. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. The widely accepted hydrodynamic theory proposes that stimuli can alter the behavior of fluid in the dentin tubules, activating intra-dental nerve fibers and causing pain. Patel VR, Shettar L, Thakur S, Gillam D, Kamala DN. A meta-analysis by Yang et al. 5 Hines D et al. Participants were recalled at interim efficacy intervals of three days, two weeks, four weeks, and six weeks for assessment of sustained relief. How does Colgate Sensitive Pro-Relief Repair & Prevent work? Oral dentifrices have been marketed for pain relief within a minute for DH. SCASS and VAS were introduced on each visit as primary and secondary outcome measures, respectively. 2016;27(4):916. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth. Moreover, there was no significant difference between dentifrices containing FCPS, Pro-argin, and 8% strontium acetate (p>0.05) on completion of trial after six weeks. J Clin Dent. [12] suggested a novel BAG component of fluoro-calcium phospho-silicate (FCPS)-containing OTC dentifrice, with the potential of fluorapatite-like crystals formation in dentin in 2017. PubMed Central Colgate* Sensitive Pro-Relief TM/MC Toothpaste with Pro-Argin TM/MC Technology is the first toothpaste that is clinically proven to provide instant & lasting relief from dentin hypersensitivity. For more great Dental Care products like toothpaste and mouthwash, continue browsing online and buy in-store at B&M. Colgate Sensitive Instant Relief Toothpaste 75ml Product code: 326795 2.49 Subject to availability - visit your nearest store ClinicalTrial.gov: National Library of Medicine (US). Correspondence to However, strontium acetate can potentially obliterate dentinal tubules by replacing the calcium ions of hydroxyapatite crystal lattice structure withstrontium ions along with its nerve depolarisation treat DH [7]. Canines and premolars are the most commonly affected teeth among 2530% of the adult population [2]. It was found statistically significant relative to control on all clinical parameters of the SCASS and VAS. J Clin Dent 2009; 20 (Spec Iss): 123-130. 0:00 / 0:30 Colgate Sensitive Pro-Relief Challenge Advert April 2012 178,990 views Mar 29, 2012 Take the Colgate Sensitive Pro-Relief Challenge to Show more 15 Dislike Share. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. https://doi.org/10.17352/2394-8418.00003. The findings agreed with another in vitro trial by Mahmoodi et al. Desensitizing toothpastes depolarize the nerves to reduce pain signals to the brain, while occlusives block the dentin tubules to prevent painful stimuli affecting dentinal fluids. Moreover, FCPS as a new bioactive material revealed promising potency of sustainable management of DH in a previously conducted trial by Ashwini et al. J Oral Rehabil. Nathoo S et al. Layer T, Hughes N. Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity. [22] reporting the instant relief from DH by 44.1% with Pro-argin on SCASS. The dropouts of the participants at each efficacy interval may be considered the weakness of this trial that was due to COVID-19 lockdown. Pro-Argin technology can be found in Colgate Sensitive Pro Relief Toothpaste, sold as Colgate Sensitive Instant Relief in the UK and elmex Sensitive Professional in Europe. The impact of FCPS, Pro-argin, and strontium acetate-based treatments of DH on the oral health-related quality of life together with the difference in the effectiveness of treatments were assessed individually rather than in groups in the current six-week trial. WHAT IS THE FLUORIDE CONTENT OF Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE? J Dent. Tandkrmen remineraliserar tandemaljen fr att ge bttre motstnd mot syraattacker. 2017;9(4):e503. Apotekets varuid 29483 Varunummer 207000 Kategori Tandkrm, Ilningar i tnderna Varumrke J Clin Dent 20 (2009), special issue 123-130, 2. * with direct application and daily brushing Benefits Exclusive Pro-Argin formula Prevents sensitivty coming back J Evid Based Dent Pract. 2019;40(10):6537 (quiz 8). Purchased in August 2019 at Coles for $5. Then, the repeated measure was obtained after five minutes for previous pain recovery, and dentifrices were provided to the patient for self-application. PubMed Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. All participants were instructed to dry the tooth surface with the cotton ball and apply a paste of about half-inch length on the dried surface for one minute, then brush the teeth twice daily after breakfast and before sleep as per directions demonstratedon the study model. Colgate Sensitive Pro Relief can be applied directly to the affected area for almost instant relief. Individuals either with dental caries, heavily restored, or cracked teeth, or with orthodontic or prosthetic appliances, or with localised or generalised gingivitis or pulpitis and heavy calculus or using any desensitising toothpaste or mouth wash or any other desensitising products up to six weeks before the study were excluded from this trial. Oral dentifrices have been marketed extensively for pain relief in one minute after topical application on sensitive teeth, with the claims of several dentists recommending the formulations containing Pro-argin and 8% strontium acetate. Innehller slipmedel med ltt polerande effekt p flckar samt fluor som minskar risken fr karies. 2016;3(1):0504. Our study included an Asian population, and most of the published literature was associated with the Caucasian population. compared Colgate Sensitive Pro Relief to another leading brand that desensitizes with a 2% potassium ion formula. The datasets analysed during the current study are available from the corresponding author on reasonable request. 2019;81:16. Dentin hypersensitivity is characterized by a short, sharp pain arising from open dentin tubules in exposed dentin in response to external stimuli, which cannot be attributed to any other defect or disease. Docimo R et al. Thank you for your feedback. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. Cite this article. This clinical trial was not funded by any agency in public, commercial or not-for-profit sectors. Ingredients *Calcium carbonate *Water The relief from sensitivity offered by Colgate Sensitive Pro Relief is proven to last. Further, it leaves a durable, mineral-enriched layer on the exposed dentin to help protect against future dentin hypersensitivity. The statistician was also kept blinded. Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Internal report 2018, 5. In this way, variability in individuals' pain response was tried to be controlled and will be discussed in part 2 of this manuscript. Akber A, Ali NS, Shabbir S, Wahid U, Farooqui WA. This binds to the negatively charged dentine surface like a magnet. J Oral Sci. There was a significant (p<0.001) reduction of 45.7% with Pro-argin, 37.6% with 8% strontium acetate, 18.1% with FCPS, and 15.2% with NaF-based dentifrices relative to baseline on SCASS after one-minute application on sensitive teeth. PubMedGoogle Scholar. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial, https://doi.org/10.1186/s12903-021-01864-x, https://clinicaltrials.gov/ct2/show/NCT04249336, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. When it begins to interfere with oral hygiene, it can also lead to poor oral health outcomes. Hence, the current study outcomes, along with previously published findings, corroborate the in vitro findings of obliteration of dentinal tubules with strontium acetate impeding painful fluid movement in dentine [29]. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. J Clin Periodontol. in 2018 [17]. Pro-Argin technology helps to seal and repair . Compend Contin Educ Dent. Gentle whitening formula. The formula consists of Arginine, an amino acid naturally found in saliva and also calcium from calcium carbonate. Compared to stannous fluoride/sodium fluoride and novamin/sodium fluoride. Zinc helps strengthen gums and prevent gum recession a key cause of sensitivity1,2,3. However, there is a substantial possibility that these fluoridated dentifrices can reduce DH. Another study by Vu Pham and Anh Nguyen reported clinical improvement in DH by 38.9% on SCASS and 40.2% on VAS for mechanical stimulated DH immediately after application of Pro-argin [25]. Colgate-Palmolive Company 2018. 1. J Clin Dent. Therefore, the current study outcomes were analysed by parametric and non-parametric statistical tests after assessing the normal distribution of data and equality of variances with Shapiro Wilk statistics. Made by one of the best-known oral care companies in Australia, it has been clinically proven to provide both instantaneous and lasting relief from sensitivity, whilst also: Fighting cavities. Yang ZY, Wang F, Lu K, Li YH, Zhou Z. Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis. Not all desensitizing toothpastes perform equally well. The Colgate Sensitive Pro Relief range features toothpastes that provide relief for sensitive teeth while addressing other common oral health concerns: Colgate Sensitive Pro Relief Repair and Prevent to protect against gingival recession. Buy Colgate Sensitive Pro Relief and get the best deals at the lowest prices on eBay! Baseline scores were recorded to measure the intensity of pain due to DH on SCASS with scores2 [22] against air blast stimulus with a triple syringe of the dental unit and on a linear VAS of 10cm length with scores4cm [23], against mechanical stimulus with a dental probe and water jet stimulus with a triple syringe. To alleviate their tooth sensitivity problem, by using Colgate Sensitive Pro-Relief will give them lasting relief and they can drink ice water freely. Therefore, in the current study, we used a dental explorer and the air blast and water jet stimuli from the triple syringe of the dental unit for testing DH to control the subjective variations in treatment response. Follow the directions for use. SJAZ has contributed to the conception, design, interpretation of results and critically revised the manuscript. J Clin Dent. Explore the videos and articles found on this page to assist in better oral care. Am J Dent. Grading of Recommendations, Assessment, Development and Evaluations. The benefits are backed by over a decade of clinical research, summarized as follows. Anvnd tv gnger dagligen. 4Intervention D denotes Colgate Total. Comparative evaluation of the efficacy of three commercially available toothpastes on dentin hypersensitivity reduction: an 8-week clinical study. 2019;88:103170. [8] that demonstrated the inherent ability of chemical interaction between arginine and type 1 collagen molecules in the salivary alkaline PH, thus resulting in endogenous calcium phosphate deposition on exposed dentinal tubules. 2012;12(3):2208. The loss of tooth enamel is the most common cause of tooth sensitivity and is not affected by cavities, gum disease, or other problems. J Dent. A systematic review. Trials. It contains clinically proven Pro-Argin technology which provides instant and lasting sensitivity relief. J Clin Periodontol. After six weeks, FCPS-based dentifrices showed greater clinical efficacy with mean scores (1.801.73) than other treatment arms for waterjet stimulated DH. J Dent Res. The clinical significance of this study can be highlighted by the fact that this was a person-centred clinical trial where patients were the prime focus where thepatients suffering from DH. Vu Pham T, Anh Nguyen T. Clinical evaluation of the desensitizing efficacy of a paste containing 8% arginine and calcium carbonate. For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. Moreover, the occluding potential of Pro-argin has also been ascertained in a previous in vitro analysis conducted by Lavender et al. Dentin hypersensitivity can have significant detrimental effects on your patients wellbeing and quality of life. 2. [33] again reported a 54% clinical reduction in DH with Pro-argin in eight weeks clinical trial using SCASS. Post-application changes on SCASS were observed after one minute, three days, two, four, and six weeks, subsequently. . J Clin Periodontol. A study evaluating the efficacy of strontium acetate relative to arginine-based dentifrices was conducted by West et al. Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. OTC dentifrices were applied and massaged gently with the applicator on at least two sensitive teeth per subject at two different sites, including cementoenamel junction and exposed dentinal surface, by the doctor in the office during the first visit. The first post-treatment measure of SCASS and VAS scores was obtained immediately after removing dentifrices from teeth. In each study, a single fingertip application of Colgate Sensitive Pro Relief was found to provide significant immediate relief relative to the comparative toothpaste, a result that was maintained over the subsequent three days with twice-daily brushing with the same toothpaste. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. 6 Ipsos, Romania Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2-week trial, 545 respondents, 2015.